Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications
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منابع مشابه
Enhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate
Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
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Mara E.M. Braga a,∗, Maria T. Vaz Pato a, Hélio S.R. Costa Silva b, Elisabeth I. Ferreira b, Maria H. Gil a, Catarina M.M. Duarte c, Hermı́nio C. de Sousa a a Department of Chemical Engineering, University of Coimbra, Pólo II, Rua Sı́lvio Lima, 3030-790 Coimbra, Portugal b Faculdade de Ciências Farmacêuticas, USP, Av. Professor Lineu Prestes 580, Bloco 13, 05508-900 São Paulo, SP, Brazil c Nutrac...
متن کاملPotential Use of Ethylene Vinyl Acetate Copolymer Excipient in Oral Controlled Release Applications: a Literature Review
Ethylene vinyl acetate copolymer (EVA) has a successful commercial history in the pharmaceutical industry as a controlled release excipient. The usage covers a wide spectrum of parenteral applications ranging from transdermal drug delivery, contraceptive insertions, subcutaneous implants and mucosal contact forms. The importance and prominence of EVA in parenteral applications has inspired rese...
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Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
متن کاملSupercritical solvent impregnation: A semiquantitative method for the evaluation of affinity between polymers and drugs
A supercritical fluid can be used in substitution of the original organic solvent for the preparation of pharmaceutical forms. The steps involved in the preparation are essentially similar to those of the traditional preparation but in this case the final purification is not required. The interest in the supercritical fluid impregnation of polymeric materials stems from the opportunity to utili...
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ژورنال
عنوان ژورنال: The Journal of Supercritical Fluids
سال: 2008
ISSN: 0896-8446
DOI: 10.1016/j.supflu.2008.05.006